In total, 317, 431, 334 and 313 unique miRNAs were downregulated, and 298, 357, 223 and 402 miRNAs were upregulated in the tauopathies, amyloidopathies, synucleinopathies and TDP43-proteinopathies, respectively (Figure 4A,B). This evidence concerns the gene TARDBP and synucleinopathy.