Although details regarding all the functions MTs can perform remain unknown, based on the available literature, the alteration in the expression of MT1 and MT2 genes is related to alterations in the early stages of bone healing that can lead not only to the failure of osseointegration of dental implants but also to the presence of low-strength bone with elevated susceptibility to periodontal disease and peri-implantitis. This evidence concerns the gene MT1F and periodontal disorder.