Recent studies have shown that the depletion of KIAA1462 decreased the expression of genes such as VCAM1 [59], which is involved in the pathogenesis of ascending aortic aneurysm through increasing the activity of MMP-2 and MMP-9 that promotes aortic aneurysm progression [60]. This evidence concerns the gene JCAD and Ascending tubular aorta aneurysm.