XIST and arthritic joint disease: The top hits included the inflammatory peptide bradykinin, which is upregulated in SLE, rheumatoid arthritis, and Hashimoto’s thyroiditis [33]; pattern recognition receptor 36, which is involved in the innate immune system [34]; and the lncRNA Xist, the principal mediator of X chromosome inactivation in females [35]—Xist has been shown to strongly contribute to B-cell modulation and sex bias in SLE and arthritis [36].