In this study, the number of resting memory CD4 T cells in schizophrenic patients was found to be significantly higher than that in healthy individuals, which may be related to the immune disorder of schizophrenic patients, and NFKBIA and BTG2 were significantly correlated with resting memory CD4 T cells, which further proves that the above two hub genes may be involved in the pathogenesis of schizophrenia. This evidence concerns the gene CD4 and immune system disorder.