The pooled ORs for NAFLD comparing T3 versus T1 of SHBG were 0.37 (95%CI 0.21–0.53, I2 = 49%, p-value = 0.07) among men and 0.40 (95%CI 0.21–0.60, I2 = 91%, p-value < 0.01) among women (Figure 4). Here, SHBG is linked to metabolic dysfunction-associated steatotic liver disease.