The association between the ageing phenotype and SPARC decline is further supported by the fact that animal models of Sparc KO exhibit ageing-like phenotypes, including accelerated degeneration [32,33], osteopenia [34], early onset of cataractogenesis [35,36], lack of immune response to lipopolysaccharides [37], and decreased bone formation [38]. Here, SPARC is linked to Osteopenia.