Moreover, Zhang et al. [61] reported that IM and GNF-5 inhibited hepatocellular carcinoma (HCC) cell growth via the downregulation of SKP2 expression and the upregulation of both p27 and p21 levels in HepG2 cells, inducing G0/G1 phase cell-cycle arrest. This evidence concerns the gene CDKN1B and hepatocellular carcinoma.