In addition, ubiquitin-specific peptidase 10 (USP10), a DUB, has been demonstrated as an SKP2 deubiquitinating enzyme and plays an integral role in the initiation and progression of CML, which modulates the SKP2/Bcr–Abl1 axis by stabilizing SKP2 [38]. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.