Risk associations with anthropometric markers related to obesity showed that the SNPs rs10244329 (OR = 1.965) and rs11760956 (OR = 1.666) found in the LEP gene were associated with a large waist circumference, rs10244329 (OR = 2.055) and rs11760956 (OR = 1.523) were associated with the waist–height index, and rs111573261 (OR = 2.399) and rs78862345 (OR = 2.399) from the LEPR gene were also associated with the same anthropometric marker. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.