Ten pathways, related to the tumor microenvironment, including interferon signaling, immunoregulatory interactions between lymphoid and lymphoid cell, complement cascade, FCGR3A mediated IL10 synthesis, chemokine receptors bind chemokine, IL3, IL-5 and GM-CSF signaling, type II interferon signaling, Toll-like receptor signaling, NKT pathway, and TNFs bind their physiological receptors were showed significantly differential enrichment in PTPRN high and low expression groups based on NES, FDR, and p-value (Figure 5, Table 3). This evidence concerns the gene IL5 and neoplasm.