Long-term IR in the brain will seriously damage the PI3K/AKT signal level pathway, resulting in the disorder of the expression of GSK3β and mTOR, which will further destroy the steady-state of brain energy metabolism, induce the deposition of Aβ and hyperphosphorylation of Tau protein, and thus cause cognitive impairment [66,67]. Here, AKT1 is linked to Cognitive impairment.