OD has also been shown to enhance the excitability of the lateral habenular nucleus (LHb) in the brain [19], and increase the expression of serotonin 2A receptors (5-HT2AR) in the hippocampus [17], which are closely related to the regulation of emotion, and CUS results in depression-like behaviors. The gene discussed is HTR2A; the disease is depressive symptom measurement.