According to previous research, 90 min after establishing OD, the expression of CRH mRNA showed an initial increase in the paraventricular nucleus (PVN) in the OD group that was followed by a return to control levels on day 14, indicating that the early stages of the occlusal disorder had a significant impact on the body, and there were adaptations to this condition over time [26]. This evidence concerns the gene CRH and osteochondritis dissecans.