Similar to our study, OD has been shown to cause decreases in GR levels in the PFC and hippocampus and an increase in the amygdala, which resulted to hypersecretion of hypothalamic CRH (Figure 2g and Figure 5a) and arginine vasopressin (AVP), promoted secretion of ACTH (Figure 2g and Figure 5b), and stimulated the synthesis and secretion of CORT [33,34] (Figure 2g and Figure 5c). Here, CRH is linked to osteochondritis dissecans.