To reinforce this concept, Landry et al. report significant differences in the GAM populations present in the GBM core, compared to those of the GBM periphery: on one side, core GAMs manifest mainly a proinflammatory phenotype correlated with Programmed cell Death-1 (PD-1) signaling; on the other, peripheral GAMs exhibit an anti-inflammatory phenotype and a strong association with NFkB signaling [52]. The gene discussed is PDCD1; the disease is glioblastoma.