GSR and colorectal carcinoma: Another study, using BALB/c mice injected with CT26 (a mouse CRC cell line), also found that the inhibition of xenograft tumors by CBD (1 and 5 mg/kg) was accompanied by the induction of apoptosis and oxidative stress parameters, including superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activity, and total antioxidant capacity [49].