In BALB/c mice injected with CT26 murine CRC cells, CBD (1 and 5 mg/kg) exerted suppressive effects on tumor growth and cellular pleomorphism by diminishing the gene expression of VEGF, a key mediator of angiogenesis in cancer, and serum levels of the proinflammatory cytokines, IL-6 and IL-8 [49]. This evidence concerns the gene VEGFA and neoplasm.