GPR55 and colorectal carcinoma: In SW480 [41], Caco-2 [43], HCT116 [43,44,45], and DLD-1 [44] CRC cells, low doses of CBD (up to 15 μM) significantly reduced cell proliferation through the direct or indirect activation of CB1, CB2, TRPV1, PPARγ, and/or G protein-coupled receptor 55 (GPR55) receptors.