In a study using lung cancer cell lines, including A549, H358, and H460 NSCLC, low doses of CBD (up to 3 μM) significantly attenuated intercellular adhesion molecule-1 (ICAM-1)-dependent cell invasion via cannabinoid receptors, TRPV1, and p42/44 mitogen-activated protein kinase (MAPK) [26]. The gene discussed is ICAM1; the disease is lung cancer.