EV-MSCs contain and carry proteins associated with tumor growth and ECM remodeling (TIMP-1, TIMP2, MMP-9, MMP-2), angiogenesis (VEGF and PDGF) [122], proliferation (EGF, TGF-β, FGFs), cytokines including IL-6, IL-8 and IL-1β [137], RNA and microRNA (Table 2). Here, CXCL8 is linked to neoplasm.