Since we have repeatedly shown that SS, MSA, and SeNP are able to induce apoptotic death of cancer cells of various lines, an increase in the expression of MAP kinases, in this case, enhances the activation of apoptosis signals, which is also evidenced by an increase in the expression of CAS-3 mRNA changes neither in the expression of ER resident selenoproteins nor in glutathione peroxidases and thioredoxin reductases. Here, SELENOS is linked to cancer.