A histological examination of lungs harvested from these various cohorts (Figure 7G–M) demonstrated that, following treatment with anti-CTLA4, there was no significant inflammatory infiltration in the transgenic-tumor-bearing mice from all three diet cohorts, indicating that there was no significant salt-mediated systemic inflammatory response in NFAT5-transgenic mice. The gene discussed is CTLA4; the disease is neoplasm.