Syed et al. [70] reported that bone-marrow-specific S1PR1 deficiency promotes early inflammation in imiquimod-induced psoriasiform dermatitis mouse models because the S1PR1 deletion alters IL-1β and VEGF generation and expression of their receptors, affecting neoangiogenesis and neolymphangiogenesis. Here, S1PR1 is linked to Psoriasiform dermatitis.