S1PR2 and atopic eczema: Park et al. [69] reported that, in a mouse model of atopic dermatitis, the administration of JTE-013, a selective antagonist of S1PR2, followed by a topical application of 2,4-dinitrochlorobenzene, decreased lymph node size and levels of inflammatory cytokines such as IL-4, IL-13, IL-17, and IFN-γ in the ear and lymph nodes, and levels of chemokines CCL17 and CCL22.