For example, Shin et al. [93] reported that topical application of HWG-35D, an SPHK2 inhibitor, improves skin lesions, serum IL-17A levels, and mRNA levels of IL-17A, K6, and K16 genes in imiquimod-induced psoriasiform dermatitis mouse model skin. The gene discussed is IL17A; the disease is Psoriasiform dermatitis.