Certain EXOs biomarkers (P-S396-tau, P-T181-tau, and Ab1–42) seem to predict the development of Alzheimer’s disease up to 10 years in advance; EXOs secreted by various parts of the kidney, contain several biomolecules that might be markers of abnormality present in the kidney [107,108]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.