Junpeng et al. recently reported that SLBCL frequently harbors PD-L1 amplifications and TP53 aberrations, showing similarities to the genetic aberrations of non-mediastinal GZL, while gene mutations enriched in DLBCL are also found in A-DLBCL and SLBCL [144,145]. Here, TP53 is linked to diffuse large B-cell lymphoma.