TP53 and B-cell non-Hodgkin lymphoma: Notably, non-mediastinal GZLs are characterized by a relatively low frequency of PD-L1 aberrations (up to 50%) [129], and by enrichment of TP53 and BCL2 mutations, and translocations of BCL2 and/or BCL6, which are frequently detected in high-grade B-cell lymphomas transformed from low-grade B-cell lymphomas [130,131].