In addition to this, input features such as pro-brain natriuretic peptide (NT-proBNP), matrix metalloproteinase-2 and 9 (MMP-2, MMP-9), leptin, low-density lipoprotein (LDL), and patient characteristics such as weight, age, and height are highly ranked as significant features for the prognosis of coronary artery disease (CAD). This evidence concerns the gene NPPB and coronary artery disorder.