Although not associated with NF1 or any type of schwannomatosis, soft tissue perineuriomas share molecular alterations with other nerve sheath tumors, including NF2 point mutations and deletions of chromosome 13 and 22q12 (NF2) and the deletion of 17q11 (including NF1) [1,51]. The gene discussed is NF1; the disease is nerve sheath neoplasm.