In critically ill COVID-19 patients, defined as individuals with respiratory failure, septic shock, and/or multiple organ dysfunction [7], the use of cardiac biomarkers for risk stratification proved to be useful [8], since elevated troponin is associated with greater mortality in COVID-19, and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) is strongly and independently associated with in-hospital mortality and other complications in patients with and without heart failure [9,10,11]. This evidence concerns the gene NPPB and COVID-19.