Although GDF-15 has been noted for its anti-apoptotic, anti-inflammatory, and antihypertrophic actions, it also noted that elevated values of GDF-15 were found to correlate with a number of cardiac diseases, including LV hypertrophy, stable coronary artery disease, myocardial infarction, and HF [11,77]. Here, GDF15 is linked to hydrops fetalis.