Although the underlying molecular pathways in CAPA were not completely disclosed, it is possible to hypothesize the main role played by COVID-19 is associated with the cytokine storm, with an elevation of IL-1, IL-6, IL-8, and IL-10, that leads to immune-dysregulation and lymphocyte exhaustion, thus facilitating the onset and progression of IPA (see Figure 1). The gene discussed is IL1A; the disease is Ito hypomelanosis.