Tan et al. [33], comparing the ability of CRP and PCT to serve as biomarkers for sepsis diagnosis show similar sensitivity (CRP: 80%, 95% CI: 63–90%, procalcitonin: 80%, 95% CI: 69–87%) but significantly lower specificity for CRP (61%; 95% CI: 50–72%) than procalcitonin (77%; 95% CI: 60–88%) [33]. Here, CALCA is linked to Sepsis.