The ACE2 rs4240157 C allele (CT+CT or CC+CG) of rs4240157 was associated with essential hypertension (EH) (p = 0.012).The findings of Pan Y et al. [57] are consistent with the observations made by Patel et al. [53], who reported ACE2 SNPs (rs2074192, rs4240157, and rs4646188) were associated with a higher risk of hypertension. Here, ACE2 is linked to hypertensive disorder.