MKI67 and choroidal melanoma: Risk stratification for the propensity to metastasize via genetic profiling for choroidal melanoma has been explored [17,42], with the results differentiating two classes: class 1 tumors are well-differentiated with low Ki-67 antibody positivity [17] (95% survival at 92 months [42]) and associate gain of 6p chromosome [42], while class 2 tumors are composed of ectodermal stem-cell-like cells and present high Ki-67 positivity [17] (31% survival at 92 months [42]) and associated loss of chromosome 3 [42], with upregulation of several genes [42].