At the 2022 national meeting of the Italian Society of Experimental Hematology, our group presented a new kind of “higher order multiplexing ddPCR” able to simultaneously measure the expression of BMI1, EZH2, USP22 and GAPDH genes in 56 patients affected by aggressive B-cell lymphoma (DLBCL). This evidence concerns the gene EZH2 and B-cell non-Hodgkin lymphoma.