In a series of 148 patients affected by WM, lymphoplasmacytic lymphoma (LPL) or IgM monoclonal gammopathy of undetermined significance (MGUS), 95% of cases showed the MYD88L265P mutation; the concordance with QT-PCR was 74%, and the discordance was always in favor of ddPCR [10]. The gene discussed is CD40LG; the disease is monoclonal gammopathy.