Furthermore, CD4+ T cells can assist cytotoxic T cells and B cells and enhance the ability of the host to clear pathogens [29] Nevertheless, persistent and chronic stimulation by the virus leads to exhaustion, which is characterised by a loss of cytokine production and sustained expression of inhibitory receptors [29] The overexpression of PD-1 and PD-L1 in patients with COVID-19 is a strong signal of T cell exhaustion, leading to decreased T cell counts. This evidence concerns the gene CD274 and COVID-19.