Potje et al. found that the treatment of human umbilical endothelial cells (HUVECs) with plasma from COVID-19 patients containing high levels of cytokines and MDA induced HS shedding and downregulated the protein levels of syndecan-1 and glypican-1 in vitro [112], indicating the involvement of cytokine- and ROS-induced glycocalyx degradation. Here, SDC1 is linked to COVID-19.