In humans, TNFR2+ Tregs in acute myeloid leukemia (AML) patients also display higher levels of C-X-C chemokine receptor type 4 (CXCR4) expression, which is positively correlated with TNFR2 expression levels on Tregs [55]. The gene discussed is TNFRSF1B; the disease is acute myeloid leukemia.