Once PTEN is downregulated, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) and signal transducers and activators of transcription 3 (STAT3) signaling pathways will be activated, resulting in increased accumulation of cancer-promoting cytokines, such as CCL2 and IL-10, and reduced antitumor immune response [58]. This evidence concerns the gene AKT1 and cancer.