In their studies, London et al. showed that activating Robo4 on endothelial cells by recombinant Slit induces enhanced localization of VE-cadherin to the cell membrane and protected mice against vascular leakage in the lung during bacterial endotoxin exposure, polymicrobial sepsis induced by cecal ligation and puncture and H5N1 influenza infection [52]. The gene discussed is CDH5; the disease is Sepsis.