Beyond sepsis, there are several other conditions, such as influenza, hantavirus, dengue or malaria, or sterile inflammation caused by trauma and major surgery, in which angiopoietin imbalance is indicative of adverse outcome [82,83,84,85,86,87], suggesting that the Ang/Tie2 axis may also display an interface for treatment strategies in other conditions of systemic inflammation. Here, TEK is linked to Sepsis.