Some authors have studied the expression of HOTTIP lncRNA in an in vitro model of ALS, represented by the SH-SY5Y cell line, and found downregulation of HOTTIP, as opposed to its upregulation in glioma and nasopharyngeal carcinoma, as well as in oral tongue squamous cell carcinoma and gastric cancer [178,179]. Here, HOTTIP is linked to central nervous system cancer.