CLOCK and Alzheimer disease: This meta-analysis revealed: a constant downregulation of miR-132-3p and miR-16 in the advanced stage of AD; no inverse relationships between miR-132-3p and circadian proteins; an inverse relationship between the downregulation of miR-16 and the upregulation of the CLOCK protein of the circadian rhythm; an upregulation of heat shock protein A-4L (HSPA4L); an inverse relationship between casein kinase 1 (CSNK1) overexpression and miRNAs involved in circadian rhythm pathways [218].