PIK3CB and Familial prostate cancer: Thus, miR-34a-5p/HIF1A, miR-34a-5p/IGFBP2 and miR-34a-5p/PIK3CB, as well as Axl, could represent possible biomarkers and therapeutic targets for prostate cancer; conversely, miR-34a-5p upregulation is associated with the development of AD [193,194].