MICA and neoplasm: Another important finding is that miR-519a-3p inhibits tumor cell killing by natural killer (NK) cells acting on the ligands UL-16 binding protein (ULBP2), NK cell group 2 receptor D (NKG2D) and major histocompatibility complex class I-related chain A (MICA) that are located on the surface of tumor cells; these ligands are crucial for the detection of tumor cells by NK cells.