Activation of the PI3K/Akt/mTOR pathway is associated with potentiation of miRNA-7 and miRNA-221 in Parkinson’s disease (PD), showing promising neuroprotective effects [230]; conversely, the overexpression of PI3K partially inverses the effects of miR-7 on cell growth inhibition and cell cycle arrest in glioma cells, while miR-221 and miR-222 reduce viability and induce apoptosis in gastrointestinal stromal tumors [231]. Here, PIK3CB is linked to gastrointestinal stromal tumor.