AKT1 and neoplasm: Therefore, the different means of modulation of miRNA-7 and miRNA-221 can act on the PI3K/Akt/mTOR pathway in some neurodegenerative and tumor processes, while, at the cellular level, the regulation of autophagy pathways mTOR, AMPK and SIRT1 may be vital for the normal regulation of circadian rhythms, [229] which, in turn, is of vital importance for preventing tumor and neurodegenerative pathologies.