CLIC3 and breast cancer: However, there was no significant overlap among upregulated genes in patients aged ≤40 years between the two datasets, except for three genes (i.e., LAMP3, HAMP, and CLIC3) as well as for two other examples of differentially expressed gene sets identified for BC <45 vs. >55 years [26] and <45 vs. >65 years [27] (Supplementary Figure S4).