Based on this, we evaluated the potential of generating normal HSPCs from AML patient-derived iPSCs adhering to the specific methods used by Sugimura et al., in which HE cells are cultured in EHT medium and have previously been shown to be conducive to TF reprogramming (Figure 2A) that resulted in SRC activity [32]. The gene discussed is TF; the disease is acute myeloid leukemia.