In all three time points, S100a8 and S100a9 were annotated in autophagy-related BPs, including autophagy (GO:0006914) and a process utilizing the autophagic mechanism (GO:0061919); meanwhile, they were also annotated in the regulation of the apoptotic signaling pathway (GO:2001233), the regulation of the intrinsic apoptotic signaling pathway (GO:2001242), and other apoptosis-related BPs. The gene discussed is S100A8; the disease is Bartsocas-Papas syndrome 1.