Furthermore, hPRPS1 and hPRPS2 have been implicated in cancer; for example, hPRPS2 knockout causes c-Myc-driven tumourigenesis and promotes the metastasis of neuroblastoma cancer, while overexpression of hPRPS1 elevates cancer cell proliferation and inhibits apoptosis in B-ALL cell lines. This evidence concerns the gene MYC and acute lymphoblastic leukemia.