On the other hand, comparison between the GRiKO DSS and the GRiKO control (Comparison 2) groups showed that LPS and IFNG were the upstream regulators activated, and IL10RA was inhibited, showing the greater change between the groups, while hepatic fibrosis, granulocyte adhesion and acute phase response signaling were the most commonly differentially regulated canonical pathways. The gene discussed is IL10RA; the disease is Hepatic fibrosis.