Consequently, intestinal LRH-1 steroidogenic function was favored in a SHP−/− mice model of lymphocytic choriomeningitis virus infection [41] and was possibly affected when PGC-1a expression was decreased, as reported with respect to the inflamed mucosa of UC patients [42] and in a murine DSS colitis model [43]. The gene discussed is NR5A2; the disease is colitis.