Consequently, intestinal LRH-1 steroidogenic function was favored in a SHP−/− mice model of lymphocytic choriomeningitis virus infection [41] and was possibly affected when PGC-1a expression was decreased, as reported with respect to the inflamed mucosa of UC patients [42] and in a murine DSS colitis model [43]. This evidence concerns the gene NR0B2 and colitis.