The first mechanism involves transacylation of acyl groups from phosphatidylcholine (PC) or phosphatidylethanolamine (PE) to CL, which is partly catalyzed by tafazzin (TAZ), a transacylase enzyme that when mutated causes defective CL remodeling and Barth syndrome (BTHS) [19]. Here, TAFAZZIN is linked to Barth syndrome.