In addition, the frequencies of CD4+ T cells in the splenocytes of DSS-induced colitis mice were also significantly decreased compared to normal control mice (11.30 ± 1.92% vs. 29.90 ± 4.14%, p < 0.01) or normal mice treated with T. halophilus (11.30 ± 1.92% vs. 28.57 ± 8.81%, p < 0.01) (Supplementary Figure S2). The gene discussed is CD4; the disease is colitis.