Previous work using a germline knockout (KO) of Camkk2 in the Pb-Cre;Ptenf/f genetic mouse model (GEMM) of prostate cancer demonstrated decreased incidence and severity of prostatic intraepithelial neoplasia (PIN) compared to Camkk2 WT mice [12]. The gene discussed is CAMKK2; the disease is prostate intraepithelial neoplasia.