CAMKK2 and Familial prostate cancer: Because CAMKK2 is associated with prostate cancer migration and invasion in vitro [3], we utilized the more aggressive GEMM, TRansgenic Adenocarcinoma Mouse Prostate (TRAMP), which can recapitulate multiple stages of prostate cancer progression including metastasis and transition to NEPC [13,14], to explore CAMKK2’s role in advanced prostate cancer in vivo.