To separate CAMKK2’s tumor extrinsic functions from its intrinsic functions in cancer, we subcutaneously injected cells from two syngeneic, Camkk2-intact/WT mouse prostate cancer lines (RM-9 and TRAMP-C2) into litter-matched Camkk2+/+ (WT) or Camkk2−/− (KO) host mice (Figure 6A). Here, CAMKK2 is linked to Familial prostate cancer.