Although average prostate (plus potential localized cancer) weights were not significantly different between cohorts (Figure 1B), TRAMP;Camkk2−/− (KO) mice developed less high-grade PIN at 15 weeks compared to the TRAMP;Camkk2+/+ (WT) cohort (Figure 1C,D). The gene discussed is CAMKK2; the disease is prostate intraepithelial neoplasia.