IGF2 and neoplasm: Interestingly, tumor risk is highly correlated with the involvement of the H19/IGF2 locus, as patients with H19/IGF2:IG-DMR GOM or with upd(11)pat have tumor risks of 28% and 16%, respectively, whereas patients with KCNQ1OT1:TSS-DMR LOM have a much lower prevalence of tumors, at 2.6% [143].