Additionally, the increased expression of CASP1, CASP3, CASP6, CASP7, CASP8, and CASP9 have all been found in the entorhinal cortex of patients with AD with severe dementia [188], suggesting that pyroptosis or apoptosis alone may not account for the full picture of cell death in AD. The gene discussed is CASP6; the disease is Alzheimer disease.