MMP9 and breast neoplasm: Together, our data suggest that MDA-EVs induce an N2-like phenotype in neutrophils marked by increased migration, viability, the release of NETs, ROS, extracellular DNA, IL-8, and VEGF, as well as increased arginase-1 expression, MMP9 activity, and mainly the ability to increase the viability of breast tumor cells (MDA-MB-231).