Many psychoactive drugs, including those used to alleviate depression and anxiety symptoms (e.g., escitalopram, bupropion), as well as stimulants that are sometimes abused (e.g., cocaine, amphetamine), predominantly act upon uptake 1 transporters, including dopamine and serotonin transporters (DAT, Slc6a3; SERT, Slc6a4). The gene discussed is SLC6A4; the disease is major depressive disorder.