However, it is now well established that HSPA1A translocates to the plasma membrane (PM) and the endo/lysosomal pathway of cancer and stressed cells [4,6,7,8], and these cells actively export HSPA1A to the extracellular medium (EM) [6,9,10,11,12,13,14,15,16,17]. The gene discussed is HSPA1A; the disease is cancer.