Furthermore, obesity promotes the initiation of numerous pro-inflammatory pathways by causing TLR4-mediated inflammatory responses that involve activation of the transcription factor NF-κB and the production of pro-inflammatory mediators such as IL-6, IL-1, and TNF-α [65,66,67,68]. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.