Mutations of BSCL2 damage different organs, such as the brain [8,9,10], mammary gland [11,12], pancreatic islets [13], and testis [14,15], which lead to the development of mutant seipin-induced genetic diseases including CGL2, progressive encephalopathy with or without lipodystrophy (PELD), also called Celia’s encephalopathy, and BSCL2-associated motor neuron diseases (also termed as “seipinopathies” by Ito and Suzuki). The gene discussed is BSCL2; the disease is congenital generalized lipodystrophy type 2.